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Concettina La Motta Selected Research

Aldehyde Reductase (Aldose Reductase)

1/2022Nature-Inspired O-Benzyl Oxime-Based Derivatives as New Dual-Acting Agents Targeting Aldose Reductase and Oxidative Stress.
12/2020Oxy-imino saccharidic derivatives as a new structural class of aldose reductase inhibitors endowed with anti-oxidant activity.
1/2019Aldose reductase inhibitors: 2013-present.
11/2018Acid Derivatives of Pyrazolo[1,5-a]pyrimidine as Aldose Reductase Differential Inhibitors.
1/2017N-(Aroyl)-N-(arylmethyloxy)-α-alanines: Selective inhibitors of aldose reductase.
1/2017Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold.
12/2012Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies.
5/2012Progresses in the pursuit of aldose reductase inhibitors: the structure-based lead optimization step.
7/2011Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications.
1/2010Anti-ischaemic activity of an antioxidant aldose reductase inhibitor on diabetic and non-diabetic rat hearts.
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Concettina La Motta Research Topics

Disease

18Neoplasms (Cancer)
09/2021 - 02/2009
11Diabetes Complications
01/2022 - 09/2009
10Thyroid Neoplasms (Thyroid Cancer)
09/2021 - 02/2011
6Anaplastic Thyroid Carcinoma
05/2018 - 04/2012
4Inflammation (Inflammations)
06/2021 - 08/2007
4Colitis
06/2021 - 08/2007
4Neoplasm Metastasis (Metastasis)
12/2020 - 05/2012
4Glioma (Gliomas)
01/2016 - 09/2008
4Cataract (Cataracts)
06/2008 - 04/2003
3Glioblastoma (Glioblastoma Multiforme)
01/2020 - 05/2010
2Hyperglycemia
01/2022 - 12/2012
2Breast Neoplasms (Breast Cancer)
01/2020 - 01/2016
2Necrosis
12/2019 - 02/2011
2medullary Thyroid cancer
11/2014 - 02/2014
2Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
10/2013 - 06/2012
2Body Weight (Weight, Body)
11/2010 - 08/2007
1Ischemia
10/2021
1Lymphangioleiomyomatosis (Lymphangiomyomatosis)
01/2021
1Carcinogenesis
01/2021
1Prostatic Neoplasms (Prostate Cancer)
12/2020
1Diabetic Retinopathy (Retinopathy, Diabetic)
12/2020
1Melanoma (Melanoma, Malignant)
01/2019
1Sarcoma (Soft Tissue Sarcoma)
05/2018
1Osteosarcoma (Osteogenic Sarcoma)
01/2016
1Leukemia
01/2016
1Medulloblastoma
01/2016
1Neuroblastoma
01/2016
1Multiple Endocrine Neoplasia Type 2b (MEN 3)
11/2014
1Sepsis (Septicemia)
06/2012
1Lung Diseases (Lung Disease)
06/2012
1Wounds and Injuries (Trauma)
06/2012
1Rheumatoid Arthritis
06/2012

Drug/Important Bio-Agent (IBA)

14EnzymesIBA
01/2022 - 09/2009
12Aldehyde Reductase (Aldose Reductase)IBA
01/2022 - 06/2008
8pyrimidineIBA
07/2016 - 08/2007
6Tyrosine Kinase InhibitorsIBA
09/2021 - 02/2011
6Antineoplastic Agents (Antineoplastics)IBA
05/2018 - 02/2009
5SolutionsIBA
12/2020 - 04/2003
4Pharmaceutical PreparationsIBA
06/2021 - 06/2011
42,4-dinitrobenzenesulfonic acidIBA
06/2021 - 08/2007
4Aldehyde DehydrogenaseIBA
01/2021 - 01/2020
4polyolIBA
01/2019 - 12/2012
4Phosphotransferases (Kinase)IBA
01/2019 - 02/2014
4Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
05/2018 - 04/2014
4ErbB Receptors (EGF Receptor)IBA
07/2016 - 02/2009
4Proteins (Proteins, Gene)FDA Link
01/2016 - 06/2011
4Adenosine (Adenocard)FDA LinkGeneric
06/2012 - 08/2007
4Ophthalmic Solutions (Eye Drops)IBA
06/2008 - 04/2003
3lenvatinibIBA
09/2021 - 01/2018
3Dexamethasone (Maxidex)FDA LinkGeneric
06/2021 - 08/2007
3Oxidoreductases (Dehydrogenase)IBA
01/2021 - 01/2017
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2018 - 04/2012
3Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
07/2016 - 04/2014
3Adenosine DeaminaseIBA
06/2012 - 08/2007
2AntioxidantsIBA
01/2022 - 07/2011
22,4-dinitrofluorobenzene sulfonic acidIBA
06/2021 - 08/2007
2Protein Isoforms (Isoforms)IBA
12/2020 - 01/2016
2pyridineIBA
12/2020 - 01/2020
2Glucose (Dextrose)FDA LinkGeneric
12/2020 - 01/2017
2CytokinesIBA
12/2019 - 08/2007
2vandetanib (ZD6474)IBA
05/2018 - 01/2018
24- chloro- N- (1,1,3- trioxo- 2,3- dihydrobenzo(d)isothiazol- 4- yl)benzamideIBA
11/2014 - 04/2012
2AmidesIBA
11/2014 - 04/2012
29-(2-hydroxy-3-nonyl)adenine (EHNA)IBA
11/2010 - 08/2007
2pyrazoleIBA
11/2010 - 08/2007
2ProdrugsIBA
11/2005 - 04/2003
2EstersIBA
11/2005 - 04/2003
2tolrestatIBA
01/2005 - 04/2003
1Reactive Oxygen Species (Oxygen Radicals)IBA
01/2022
1AMP-Activated Protein KinasesIBA
06/2021
1acadesineIBA
06/2021
1Biomarkers (Surrogate Marker)IBA
01/2021
1rasagiline (Azilect)FDA Link
01/2021
1lipoarabinomannan (LAM)IBA
01/2021
1Clorgyline (Clorgiline)IBA
01/2021
1Histamine (Histamine Dihydrochloride)FDA Link
01/2021
1Histidine (L-Histidine)FDA Link
01/2021
1Histamine H1 Receptors (Histamine H1 Receptor)IBA
01/2021
1Loratadine (Alavert)FDA Link
01/2021
1Sirolimus (Rapamycin)FDA Link
01/2021
1AldehydesIBA
12/2020
1Small Interfering RNA (siRNA)IBA
01/2020
1VimentinIBA
01/2020
1ApigeninIBA
12/2019
11,2,4-triazoleIBA
01/2019
1NADP (NADPH)IBA
01/2017
1Temozolomide (Temodar)FDA LinkGeneric
01/2016
1Carbonic Anhydrases (Carbonic Anhydrase)IBA
01/2016
1Plasminogen InactivatorsIBA
01/2016
1Adenosine Triphosphate (ATP)IBA
01/2016
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
01/2016
1Phospholipase DIBA
01/2016
1Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
01/2016
1src-Family KinasesIBA
01/2016
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
01/2016
1tyrosine receptor (receptor, tyrosine)IBA
02/2014
1PolymersIBA
10/2013

Therapy/Procedure

4Therapeutics
01/2021 - 01/2012
2Heterologous Transplantation (Xenotransplantation)
08/2014 - 02/2011
1Drug Therapy (Chemotherapy)
11/2017